Bone drug can fight breast cancer - 2

The study was sponsored by Zometa's maker, Swiss-based Novartis AG, and the study leader consults for the company. With doctor fees, a Zometa infusion can run more than $1,200. In the study it was given every three weeks for four to six months.

Known side effects of Zometa and other bone-building bisphosphonate drugs like Fosamax include bone, joint or muscle pain and in rare cases, jawbone decay. They are mainly used to treat osteoporosis.

Also at the conference, several reports strengthened evidence that newer hormone-blockers called aromatase inhibitors, or AIs, do a better job of preventing cancer recurrences and may give a slight survival advantage over the long-used drug tamoxifen.

These drugs work against estrogen, which helps most breast tumors grow, and are given for about five years after surgery for early stage breast cancer to prevent its return.

Tamoxifen has been used for decades and is sold in generic form for about $70 a month. The newer drugs cost around $300 and come in three brands: AstraZeneca PLC's Arimidex (anastrozole), Pfizer Inc.'s Aromasin (exemestane) and Novartis' Femara (letrozole). They only work in women after menopause.

Doctors already know that women who take these newer drugs either as initial treatment or after a few years of tamoxifen have better chances of staying cancer-free. But which of these approaches is best is not known.

Results of a study led by Novartis consultant Dr. Henning Mouridsen of Copenhagen University Hospital in Denmark mostly were a draw. There were trends toward improved survival for women starting on Femara, but the differences were so small they could have occurred by chance alone.

ref: the timesofindia

Bone drug can fight breast cancer - 1

New research adds fresh hope that a drug that strengthens bones might also fight breast cancer. Women who were given the drug, Zometa, as part of their initisl treatment had greater tumor shrinkage and were less likely to need radical surgery, according to a prelimenary study reported Thursday at a cancer conference in Texas.

In June, doctors were stunned when a big study found that Zometa — given to prevent bone loss caused by certain cancer treatments — also greatly cut the risk that cancer would recur in women who developed the disease before menopause.

Cancer specialists are eagerly awaiting the final results of a second, ongoing study testing Zometa in 3,360 women who had breast cancer after menopause — a much more common situation.

Its leaders gave a mini-report Thursday on 205 participants who had chemotherapy to try to shrink their tumors before surgery.

Those given infusions of Zometa along with chemo had a third more tumor shrinkage and as a result, were less likely to need their whole breast removed versus just the lump, said study leader Dr. Robert Coleman of the University of Sheffield in England.

Eleven percent of Zometa takers had a complete response to treatment — no evidence of cancer in their breasts or lymph nodes — versus 6 percent of women given chemo alone.

Partial studies like this are not enough to change practice, but these results are surprising and deserve further testing, said Dr. Eric Winer of the Dana-Farber Cancer Center in Boston. Such significant benefits from the bone drug before surgery "is not something I would have expected," he said.

Winer had no role in the work or financial ties to any breast cancer drugmakers. He also is a spokesman for the American Society of Clinical Oncology, the largest group of doctors who treat cancer.

ref: thetimesofindia

Aerobics help in weight loss

Sixty minutes of vigorous aerobic exercises on a treadmill is better than 90 minutes of weight-lifting in suppressing appetite.

Aerobics do so by modifying release of two key appetite hormones, ghrelin and peptide YY, while weight-lifting affects the level of only ghrelin, according to a new study.

This line of research may eventually lead to more effective ways to use exercise to help control weight, according to co-author, David J. Stensel of Loughborough University in Britain. There are several hormones that help regulate appetite, but the researchers looked at two of the major ones, ghrelin and peptide YY. Ghrelin is the only hormone known to stimulate appetite. Peptide YY suppresses appetite.

Ghrelin was discovered by researchers in Japan only about 10 years ago and was originally identified for its role as a growth hormone. Only later did its role in stimulating appetite become known. Peptide YY was discovered less than 25 years ago.

In this experiment, 11 male university students did three eight-hour sessions. During one session they ran for 60 minutes on a treadmill, and then rested for seven hours.

During another session they did 90 minutes of weight lifting, and then rested for six hours and 30 minutes. During another session, the participants did not exercise at all, said a Loughborough release.

During each of the sessions, the participants filled out surveys in which they rated how hungry they felt at various points. They also received two meals during each session. The researchers measured ghrelin and peptide YY levels at multiple points along the way.

They found that the treadmill (aerobic) session caused ghrelin levels to drop and peptide YY levels to increase, indicating the hormones were suppressing appetite. However, a weight-lifting (non-aerobic) session produced a mixed result. Ghrelin levels dropped, indicating appetite suppression, but peptide YY levels did not change significantly.

Based on the hunger ratings the participants filled out, both aerobic and resistance exercise suppressed hunger, but aerobic exercise produced a greater suppression of hunger.

The changes the researchers observed were short term for both types of exercise, lasting about two hours, including the time spent exercising, Stensel reported.

The study appears in the online edition of The American Journal of Physiology-Regulatory, Integrative and Comparative Physiology.

fer: thetimesofindia

Nuts help cut risk of heart disease

Good morning friends. This article is good for the nuts lovers. I’m sure that everyone will eat nuts to prevent heart ailment. This has reference to The Times of India.

Here's a health tip in a nutshell: Eating a handful of nuts a day for a year — along with a Mediterranean diet rich in fruit, vegetables and fish — may help undo a collection of risk factors for heart disease.

Spanish researchers found that adding nuts worked better than boosting the olive oil in a typical Mediterranean diet. Both regimens cut the heart risks known as metabolic syndrome in more people than a low-fat diet did.

"What's most surprising is they found substantial metabolic benefits in the absence of calorie reduction or weight loss," said JoAnn Manson, chief of preventive medicine at Harvard's Brigham and Women's Hospital. In the study, the people who improved most were told to eat about three whole walnuts, seven or eight whole hazelnuts and seven or eight whole almonds. They didn't lose weight, on average, but more of them succeeded in reducing belly fat and improving their cholesterol and blood pressure.

Manson, who wasn't involved in the study, cautioned that adding nuts to a western diet — one packed with too many calories and junk food — could lead to weight gain and more health risks.

"But using nuts to replace a snack of chips or crackers is a very favorable change to make in your diet," Manson cautioned.

The American Heart Association says that over 50 million Americans have metabolic syndrome, a combination of health risks, such as high blood pressure and abdominal obesity.

Nuts help people feel full while also increasing the body's ability to burn fat, said lead author Jordi Salas-Salvado of the University of Rovira i Virgili in Reus, Spain.

"Nuts could have an effect on metabolic syndrome by multiple mechanisms," Salas-Salvado said. Nuts are rich in anti-inflammatory substances, such as fiber, and antioxidants, such as vitamin E. They are high in unsaturated fat, a healthier fat known to lower blood triglycerides and increase good cholesterol.

Obese kids risk thyroid damage

Good morning friends. Obese kids out there. Being fat is not good. You may be looking healthy but the truth is it has a it's not good and it creates damage.

Obesity may cause inflammation that damages the thyroid, which secretes hormones to regulate metabolism and other important functions, Giorgio Radetti of the Regional Hospital of Bolzano in Italy and colleagues said.

They evaluated 186 overweight and obese children for about three years, testing thyroid hormone levels and thyroid antibodies and imaging the thyroid gland using ultrasound.

“We found an association between body mass index and thyroid hormone levels which suggests that fat excess may have a role in thyroid tissue modification,” Radetti said.

ref: thetimesofindia

Fungus can slash heart attack, obesity

Good morning friend. We all know teenage very seldom or some how i may say wer not reading newspapers. They are using computers to surf and to search anything. They are crazy about computers. That's why I'd like to share with all of you what I have read in The Times of India.

A vegetarian superfood, which is made from fungus, can cut the risk of having a heart attack and help people stay slim.

What's more, the miracle item can also slash the risk of suffering from diabetes, says the study published in the British Nutrition Foundation's journal.

According to experts, a diet rich in mycoprotein can lower cholesterol and could help reduce high levels of blood glucose and insulin. It may also prolong a feeling of fullness after a meal, potentially helping people to slim.

Mycoprotein is a meat-free form of high quality protein which is made by adding oxygen, nitrogen, glucose and minerals to a natural fungus called Fusarium venenatum.

It is found in meat free products like mince, sausages, escalopes, deli food and ready meals.

To reach the conclusion, the researchers reviewed data relating to the benefits of mycoprotein, a key ingredient in meat substitutes like Quorn.

The review discovered reported cholesterol reductions of up to 14 per cent among people eating 190 grammes of mycoprotein a day for three weeks. A single serving of meat substitute mince contains 80 grammes of mycoprotein, the study found.

Also a reduction in cholesterol of around 10 per cent among people with elevated cholesterol levels eating 120 to 140 grammes of mycoprotein a day was reported. As for the expanation, the researchers said that mycoprotein might be useful in the management of obesity and type 2 diabetes because it slows the transport of food sugars from the stomach to the bloodstream. This has the effect of lessening the peaks and troughs often seen in blood glucose and insulin levels after meals.

"Mycoprotein is a really healthy food and the bonus is all these benefits on top. If it fills you up and helps to reduce the impact of blood sugar and reduce cholesterol, it sounds like it is a bit of a superfood," the Daily Express quoted nutritionist Angela Dowden, as saying.

Treatment for food allergy on the anvil

Scientists across Europe are working towards developing a treatment for one of the most common and dangerous conditions for humans- food allergy.

The initiative called the Food Allergy Specific Therapy (FAST) research project has Dr Clare Mills of the Institute of Food Research as a lead partner.

"All people with food allergy can do is avoid the foods to which they are allergic. The threat of severe anaphylaxis has a great impact on their quality of life," he said.

Attempted treatment with allergen-specific immunotherapy, where a patient received monthly injections with an allergen extract for three to five years, failed because it could cause anaphylaxis as a side effect.

Anaphylaxis is a severe allergic reaction involving the whole body, often within minutes of exposure to the allergen.

Peanut allergy is the most widely known cause, but other causes of anaphylaxis include other foods, insect stings, latex and drugs. If untreated in time it can be fatal.

In the FAST project, scientists will use modified variants of allergic proteins that are hypoallergenic and therefore safer. The proteins will be purified making them more effective and making it easier to control the dose.

Almost 90 percent of all food allergies are caused by about 10 foods.

Allergies to fish and fruit are among the most common in Europe. In fish allergy the protein responsible is parvalbumin and in fruit it is lipid transfer protein (LTP). Modified hypo-allergenic versions of these proteins will be produced at tested as potential treatments.

"We are hoping for a cure that will allow people to eat fish or fruit again. But a significant reduction of sensitivity would already be a great step forwards," said Dr Ronald van Ree from the Academic Medical Center at the University of Amsterdam.

He added: "The risk of unintentional exposure due to cross-contamination of foods, or while eating in restaurants or at parties, will decrease. This will take away lot of the anxiety that has a negative impact on the quality of life of food allergy sufferers." (ANI)